The LM10 series are monolithic linear ICs consisting of a precision reference, an adjustable reference buffer and an independent, high-quality operational amplifier. The unit can operate from a total supply voltage as low as 1.1 V or as high as 40 V, drawing only 270 μA.
The Fas cell signaling pathway has a central role in the physiological regulation of programmed cell death (also called apoptosis) and has been implicated in the pathogenesis of various malignancies and diseases of
LM10 does not inhibit IDO and has a high solubility and bioavailability without obvious signs of toxicity . The plasma concentration of LM10 after oral administration of 160 mg/kg/day is between 20 and 40 μg/mL (87-175 μM), a concentration about 40 times above the IC 50 measured in the cellular assay performed with the physiological concentration of plasma